Apigenin XT

Advanced Muscle, Brain, & Longevity Support

Advanced Absorption Formula

200 MG. Apigenin Per Capsule

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200 Mg. ApiPure™ Apigenin

25 Mg. AstraGin®

5 mg. Bioperine®

24,000 Mg. (24 Grams) Apigenin Per Bottle

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Apigenin XT delivers 200 mg. of premium ApiPure™ Apigenin per capsule – a natural flavonoid known for a wide range of potential benefits including cellular protection, positive mood, relaxation, and healthy aging & longevity benefits.

Apigenin XT contains 400% more Apigenin than most brands plus 2 clinically researched absorption enhancers for maximum results.

Apigenin XT Highlights/Supports:

• NAD+ Levels
• Positive Mood
• Cognitive Support
• Skin & Hair Health
• Cardiovascular Health
• Stress & Anxiety Support
• Relaxation & Restful Sleep
• Improved Sense of Well-Being
• Anti-Inflammatory & Antioxidant Support
• Healthy Aging & Longevity Support

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Who is Apigenin XT Designed For?

• Individuals interested in healthy aging, longevity, vitality, and NAD+ support.
• Anyone interested in stress, anxiety, and mood support.
• Those interested in hair and skin health support.
• People interested in cognitive and nootropic support.
• Anyone interested in improved relaxation and sleep quality.
• Individuals seeking natural muscle-building support.

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Why Choose Apigenin XT?

• High Potency: 200 mg. Apigenin Per Capsule
• Enhanced Absorption: AstraGin® and Bioperine®
• Great Value: 120 Veg Capsules | 24 Grams Apigenin Per Bottle
• Gluten Free, Soy Free, & Vegan Friendly
• Third-Party Tested & Manufactured in a GMP-Certified Facility

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What is Apigenin XT?

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Apigenin is a natural plant flavonoid found in chamomile, parsley, celery, and other plants. It has been widely studied for its variety of remarkable benefits, particularly for its role in promoting relaxation, protecting cells from oxidative stress, and supporting metabolic and cognitive health.

As if that wasn’t exciting enough, recent research has shown exciting potential for Apigenin promoting muscle building, hormone balance, and a variety of healthy aging & longevity benefits.

This makes Apigenin an exciting and versatile ingredient for athletes, biohackers, general health & wellness minded individuals, and healthy aging & longevity enthusiasts.

Apigenin XT delivers 200 mg. of premium ApiPure™ Apigenin per capsule – 400% more Apigenin than most brands plus 2 clinically researched absorption enhancers for maximum results.

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Let’s Examine Some of the Potential Benefits

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NAD+ Levels/NAD Production:

NAD+ is a vital coenzyme found in every cell in your body, primarily responsible for converting food into energy and repairing damaged DNA. Its primary function is to transfer energy from the food that you eat to cellular powerhouses (mitochondria) to produce ATP, powering nearly every physiological process needed to sustain life. It serves as the primary ‘shuttle’ that moves electrons between chemical reactions to keep your cells functioning and energized.

NAD+ Core Functions in the Body:

• Cellular Energy Production: NAD+ acts as an electron shuttle (converting to NADH and back) that accepts and donates electrons during cellular respiration, driving the creation of ATP (the body’s primary energy currency) within the mitochondria, which is essential for metabolism and generating cellular energy.
• DNA Repair & Protection: It makes enzymes called sirtuins and PARPs that help fix damaged genetic material and protect cells against stress.
• Gene Expression: NAD+ acts as a co-substrate for enzymes that control which genes are turned on or off, which plays a major role in cellular longevity.
• Metabolic Regulation: It supports tissue homeostasis and regulates how the body manages inflammation, insulin sensitivity, and blood sugar.

NAD+ levels naturally get lower as we age, in a large part due to an enzyme called CD38.

Apigenin has been shown to be a potent inhibitor of CD38.

Here are some details of this process:

• CD38 is an enzyme that breaks down NAD+.
• CD38 expression naturally increases with age, which accelerates the depleting of NAD+ levels. This decline is linked to age-related metabolic issues and inflammation.
• CD38 Inhibition: By inhibiting CD38, Apigenin reduces the degradation of NAD+ levels.
• Raises Cellular NAD+: This inhibition helps to preserve and elevate NAD+ levels.
• Sirtuin Activation: Higher NAD+ levels support the increased activity of Sirtuins (such as SIRT1 and SIRT3), thereby promoting cellular health and metabolism. Sirtuins are a specialized family of proteins that function as enzymes that help regulate cellular health, reduce oxidative stress, and assist in DNA repair.
• Mitochondrial Function: Boosting NAD+ may help restore mitochondrial activity, thereby generating more cellular energy (ATP).
• Metabolic Health: Protecting NAD+ and promoting sirtuin activity may help support an improved metabolic profile.
• Reduced Senescence: Improving NAD+ levels may help reduce senescent (aging) cells, which allows new cells to flourish and regenerate.

Apigenin XT provides a potent 200 mg. per capsule of ApiPure™ Apigenin + 2 clinically researched absorption enhancers to help make sure that you get the most out of your NAD+ protocol!

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Healthy Aging & Longevity:

Apigenin supports healthy aging and longevity through a variety of pathways, many of which are discussed in more detail in their own respective sections of this write up.

Key Healthy Aging & Longevity Mechanisms Include:

• Boosts NAD+ Levels: Apigenin has been shown to inhibit CD38, an enzyme that breaks down NAD+. By helping to preserve or increase NAD+ levels, Apigenin may support improved cellular energy production and mitochondrial health.
• Mitochondrial Health: Apigenin supports mitochondrial health by acting as a powerful antioxidant, preserving cellular energy (NAD+), and regulating mitochondrial turnover (mitophagy). Mitophagy is the process of clearing out damaged, dysfunctional mitochondria while preventing the inappropriate death (apoptosis) of healthy cells. Apigenin is also thought to support mitochondrial fusion (the joining together of mitochondria for greater efficiency).
• Reduced Senescence (Cellular Aging): Apigenin has been shown to help suppress senescence-associated secretory phenotype (SASP), reducing chronic inflammation (inflammaging) by inhibiting pathways like NF-κB and p38-MAPK.
• Sirtuin Activation: Apigenin may support increased activity of Sirtuins (such as SIRT1 and SIRT3), which are a specialized family of proteins that function as enzymes that help support cellular health, reduce oxidative stress, and assist in DNA repair.
• Cognitive Health/Neuroprotection: Apigenin is being studied for its role in supporting improved neuron formation and strengthening connections between brain cells. It is thought to play a role in supporting neurotransmitter activity, neuronal signaling, and stress response, which may contribute to improved cognitive health. It has also been shown in animal models to support memory and learning and have protective effects against neuroinflammation.
• Improved Sleep Quality: Apigenin supports restful sleep by gently binding to the GABA-A receptors and supporting an upregulation in GAD67. Apigenin isn’t a ‘knock you out’ sleep aid, it is a natural ingredient that helps to relax your mind and allows you to go to sleep and experience a more restful and restorative night’s sleep.
• Stress, Anxiety, and Mood Support: Apigenin is well known for its relaxation without sedation properties and helps support relaxation and positive mood through multiple pathways, including GABA-A receptor modulation, GAD67 upregulation, improved neurotransmitter balance, and more.
• Cardiovascular Support: Research suggests that Apigenin may support heart and blood vessel health through its antioxidant, anti-inflammatory, and vasodilatory properties. It is being researched for its potential role in supporting improved endothelial health, reduced arterial stiffness, down-regulating inflammatory pathways like NF-κB, and more.
• Anti-Catabolic (Muscle Preservation) Properties: Muscle loss is an often overlooked, but very important aspect of healthy aging and longevity. Apigenin may support the retention/preservation of muscle tissue via a variety of pathways discussed in the muscle building section of this write up.
• Anti-Inflammatory Support: Apigenin has been shown to have anti-inflammatory properties and support a healthy inflammatory response by influencing certain signaling pathways and modulating inflammatory markers.
• Antioxidant Support: Apigenin exhibits potent antioxidant properties, which may help to neutralize free radicals and protect cells from damage caused by oxidative stress – two factors heavily linked to aging and chronic inflammation

Apigenin XT contains a potent 200 mg. of ApiPure™ Apigenin per capsule + 2 clinically researched absorption enhancers to help you get the most out of your health aging & longevity regimen!

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Relaxation and Restful Sleep:

Relaxation without sedation – is a big reason that people love Apigenin.

Apigenin is unique in that it helps promote relaxation and restful sleep, but doesn’t make most people feel tired, meaning that it can be taken during the day or at bedtime.

Apigenin helps promote restful sleep, not by acting as a traditional sleep aid that has a knock you out effect, but by helping you relax and helping to quiet your racing mind so that you can go to sleep.

Dual-Action Approach to Relaxation and Restful Sleep:

Apigenin supports relaxation and restful sleep through a dual-layered approach that offers the fast-acting potential benefits of GABA-A binding with the longer-term benefits of GD67 upregulation.

Here is an overview in simple terms:

• GABA-A Receptor Interaction: Apigenin supports relaxation by gently binding to GABA-A receptors in the brain. By increasing GABA activity, it helps to slow down overactive neural activity, thereby reducing anxiety and promoting relaxation.
• GAD67 Upregulation Properties: Emerging research shows that Apigenin helps support and upregulate the activity of a very important enzyme for GABA synthesis, GAD67, which catalyzes the reaction that turns glutamate into GABA. By supporting an increase in GAD67, Apigenin may help your brain naturally clear out excess, anxiety-inducing glutamate and turn it into calming GABA.
• The GABA Factory: GAD67 is a crucial enzyme in your brain responsible for converting glutamate (your primary excitatory “go-go-go” neurotransmitter) into GABA (your primary inhibitory “slow-down” neurotransmitter). An analogy would be to think of GAD67 as the GABA factory.
• GABA-A Receptor Binding: While GAD67 increases the total supply of GABA in your brain, Apigenin’s direct binding to GABA-A receptors is what supports a faster, more immediate sensation of calm. It could be thought of as amplifying the GABA that is already floating around, offering faster relief from stress and racing thoughts.
• Working Together: You can think of the direct GABA-A receptor activation as a more fast-acing mental and physical calmness and relaxation, whereas the GAD67 enzyme interaction could be thought of as a long-term baseline support for neurotransmitter balance and improved sleep quality.

By working on both fronts – increasing the production of GABA via GAD67 and making the brain more sensitive to it via GABA-A receptors, Apigenin provides an efficient, dual layered approach to relaxation.

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Stress, Anxiety, & Mood Support:

Relaxation without sedation and Apigenin’s interactions with the GABA-A receptors and GAD67, as explained in detail above, carry over into how Apigenin may promote stress, anxiety, and mood support.

Apigenin promotes relaxation and mood stability primarily by acting on the central nervous system, including some of these key mechanisms:

• GABA-A Receptor Modulation: Apigenin has been shown to gently bind to GABA-A receptors, which may promote a sense of calmness and reduce mental restlessness.
• GAD67 Upregulation: Apigenin has been shown to support and upregulate the activity of GAD67, a very important enzyme for GABA synthesis that catalyzes the reaction that turns glutamate into GABA. By supporting an increase in GAD67, Apigenin may help your brain naturally clear out excess, anxiety-inducing glutamate and turn it into calming GABA.
• Neurotransmitter Balance: Studies indicate that Apigenin may help regulate certain mood-boosting neurotransmitters like serotonin, dopamine, and epinephrine, which are often depleted by chronic stress. This may help support emotional stability and a more resilient, positive mood.
• Brain-Derived Neurotrophic Factor (BDNF): Apigenin has been shown to support the upregulation of the cAMP-CREB-BDNF signaling pathway in the brain, which is a master regulatory cascade in the brain that influences neuroplasticity, cognitive health, memory, learning, and stable mood behavior.
• Cortisol Control Support: Research suggests that cortisol may help lower cortisol, the primary stress hormone.

Apigenin is an excellent choice for many individuals looking for a non-sedating natural approach to daily stress management, emotional balance, and cognitive resilience.

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Cognitive, Brain Health, & Nootropic Properties:

Apigenin is being studied for its role in supporting improved neuron formation and strengthening connections between brain cells. It is thought to play a role in supporting neurotransmitter activity, neuronal signaling, and stress response, which may contribute to improved cognitive health. It has also been shown in animal models to support memory and learning and have protective effects against neuroinflammation.

Apigenin interacts with brain receptors, such as GABA-A, promoting a calming effect that may help reduce mental stress and support mental clarity, focus, and mood stability. It may also encourage the growth of new brain cells through a process known as neurogenesis, potentially supporting long-term brain health and memory.

In addition to the above listed potential nootropic and cognitive health benefits, Apigenin has been shown to potentiate alpha 7 nicotinic acetylcholine receptors (α7 nAChR), a fascinating and unique pathway for nootropic effects because it amplifies naturally occurring cholinergic signals to support attention and memory.

In summary, Apigenin may support:

• Improved focus and mental clarity
• Memory and learning
• Mood stability
• Relaxation without sedation
• Improved response to stress
• Enhanced sleep quality and rejuvenation
• Neurogenesis (the formation of new brain cells)

Apigenin XT contains a potent 200 mg. of ApiPure™ Apigenin per capsule + 2 clinically researched absorption enhancers and makes an excellent addition to your daily nootropic and cognitive health supplement regimen!

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Skin & Hair Health:

Apigenin is believed to support skin health primarily through its anti-inflammatory and antioxidant actions. It may help protect against UV induced damage, support the skin barrier, and potentially reduce symptoms of skin inflammation.

Here are some key mechanisms:

• Anti-Inflammatory: Apigenin may reduce skin inflammation by downregulating inflammatory markers (like COX-2 and NF-κB) and pro-inflammatory cytokines.
• Antioxidant Properties: Apigenin may help protect skin cells from oxidative stress, a key factor in skin aging and UV damage.
• UV Protection: Studies suggest that Apigenin may reduce UV-skin damage and help prevent the formation of dimerized DNA in skin cells caused by sun exposure.
• Collagen Support: Research indicates that Apigenin may promote collagen synthesis by protecting dermal fibroblasts, thereby potentially aiding in skin elasticity.
• Skin Barrier: Apigenin may support improving skin barrier function and increasing hydration.

Apigenin has some really good real-world feedback from individuals saying that it helps with hair growth, but up to this point the studies on this subject remain limited to animal and cell-based studies. It is thought to support hair health through its antioxidant and anti-inflammatory properties and is thought to support hair health by prolonging the anagen (growth) phase of hair follicles, reducing perifollicular inflammation, and inhibiting specific proteins that lead to hair thinning.

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Muscle & Strength:

Apigenin has anabolic (muscle building) and anti-catabolic (helps prevent muscle breakdown) properties, making Apigenin an excellent ingredient to support building and maintaining muscle tissue.

 

NAD+ Levels

Apigenin has been shown to inhibit the CD38 enzyme, an enzyme that is responsible for breaking down NAD+ in the body. NAD+ is critical for energy metabolism, mitochondrial function, and muscle recovery.

By supporting higher NAD+ levels, Apigenin may help enhance cellular energy production (ATP), improve muscle recovery and endurance, and reduce fatigue and support muscle repair.

This mechanism is especially important for those focused on performance, recovery, and/or long-term muscle maintenance.

Korea Food Institute Study:

Apigenin’s natural muscle building and strength benefits were first discovered by researchers at the Korea Food Research Institute.

In the initial study that led to Apigenin’s popularity for building muscle, scientists began experimenting with Apigenin in mice and found that the mice receiving Apigenin had significant muscle mass gains over the mice not receiving it.

The greater the dose of Apigenin the mice took, the larger the quad size increase!

Study Controls:

The study was split into a control group, a lower dose Apigenin group, and a higher dose Apigenin group.

Study Results and Observations:

Researchers demonstrated that Apigenin significantly enhanced muscle growth through its effect on myogenic regulatory factors (proteins responsible for muscle cell development and regeneration) such as MyoD and myogenin, and also that it activates the p38 MAPK pathway, which plays a role in skeletal muscle regeneration.

Researchers observed the greater the dose of Apigenin that the mice took, the larger their quadriceps size increased.

Study Highlights:

Apigenin was shown in the study to have a beneficial role on various muscle building factors, such as:

• MyoD & Myogenin: Researchers found that Apigenin increased the expression of MyoD and myogenin, two key markers of muscle cell development and regeneration.
• Myotube Formation: Apigenin stimulated myotube formation (the development of mature muscle fibers), showing a direct anabolic effect on muscle tissue.
• p38 MAPK: The study concluded that Apigenin promotes muscle hypertrophy by activating the p38 MAPK pathway, which plays a key role in skeletal muscle growth and regeneration.
• PGC-1-alpha: The study showed increases in PGC-1-alpha, a signal molecule that stimulates cells to manufacture more mitochondria.
• PRMT7: Apigenin was shown to trigger anabolic pathways by activating the enzyme protein arginine methyl transferase-7 (Prmt7) – also shown after in vitro with C2C12 muscle cells.
• MHC: Apigenin was shown to increase the production of contractile muscle protein (MHC).
• Anabolic Signaling Activation: The study showed that Apigenin upregulated growth factors like IGF1 and IGF2 and boosted downstream Akt and mTORC1 activation to promote larger muscle fiber size and overall muscle function.

Here are a couple of significant quotes from researchers:

• “We found that apigenin increases quadriceps muscle weight in mice and increases their running distance on an accelerating treadmill.”
• “These events are attributable to upregulation of the Prmt7-PGC-1-alpha-GPR56 signaling pathway.”

• “We also found that apigenin induces myogenic differentiation by regulating Prmt7-p38-myoD and the Akt-S6K1 pathway in C2C12 cells.”
• “These results suggest that apigenin could be used as a functional food to prevent muscle loss and enhance muscle function.”

In summary, Apigenin is an exciting ingredient that may help support building and maintaining muscle tissue from a variety of different pathways.

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Metabolic Health:

Emerging research suggests that Apigenin may have a beneficial role in weight management by affecting energy metabolism and inflammatory balance. Research suggests that it also may help promote healthy blood sugar levels and insulin secretion.

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Cardiovascular Support:

Research suggests that Apigenin may support heart and blood vessel health through its antioxidant, anti-inflammatory, and vasodilatory properties. It is being researched for its potential role in supporting improved endothelial health, reduced arterial stiffness, down-regulating inflammatory pathways like NF-κB, and more.

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Prostate Support:

Apigenin has been clinically studied and shown to have promising potential to support prostate health. This has led to Apigenin becoming one of the fastest growing ingredients in terms of popularity in this supplement category.

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Anti-Inflammatory Support

Research suggests that Apigenin may help support a healthy inflammatory response by influencing certain signaling pathways and modulating inflammatory markers.

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Antioxidant Support:

Apigenin exhibits potent antioxidant properties, which may help to neutralize free radicals and protect cells from damage caused by oxidative stress – two factors heavily linked to aging and chronic inflammation.

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Stacking & Synergy:

Apigenin XT can be taken with Focus XT, Cardiovascular Support XT, Blood Pressure Support XT, Mood Support XT, Joint Support XT, or a variety of other SNS products to help you reach your individual goals.